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led astray

January 2013

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I've been doing a little bit of research and found this:
Recent research has reported that serotonin is linked with normal
gastrointestinal (GI) functioning. Serotonin is a neurotransmitter, or
chemical, that delivers messages from one part of your body to
another. Ninety-five percent of the serotonin in your body is located
in the GI tract, and the other 5 percent is found in the brain. Cells
that line the inside of the bowel work as transporters and carry the
serotonin out of the GI tract. People with IBS, however, have
diminished receptor activity, causing abnormal levels of serotonin to
exist in the GI tract. As a result, they experience problems with
bowel movement, motility, and sensation—having more sensitive pain
receptors in their GI tract.

I am taking a seratonin re-uptake inhibitor. I wonder if it affects
seratonin in my intestines. It is an easy explanation for why I've
been having so much trouble.

Another site said symptoms of IBS are very similar to symptoms of
colon cancer, which my grandfather died of, as did his sister. And my
aunt had a tumor removed from "her belly" (I was 8 or so) which grew
back and was removed again. So, yeah. I'm hoping it's a seratonin
thing. The main thing the ssri is doing is artificially increasing
the circulating levels of the amitryptaline (the one that worked over
night) and I might be able to adjust my meds to not have to take it
anymore, returning my system to normal.


SSRI's are known for causing differences in the motility and function of the GI tract, though each drug/person combination is unique.

However, with tricyclics, the most common change is a slower motility (some people experience constipation, for example).

On the whole, the better your seratonin balance in the brain, it reflects well in the rest of the body. But, if you're experiencing an upswing of IBS symptoms, it could be secondary to coming off THC, or could also benefit from some yoga focusing on the abdomen. Helps get things back in order a bit.